Analytical Method — into Practice
نویسندگان
چکیده
It is well-known, that healthy people’s body produces natural autoantibodies (NAAB) to antigens of its own organs and tissues in the course of the whole life. It is anticipated that such NAAB take part in body clearance from natural catabolism products and participate in regulation of many physiological functions [1, 2]. Serum content of NAAB of the same specificity in healthy people is relatively stable and levels of their synthesis and secretion normally vary individually very little and very little depend on sex and age [1]. It has been established that, normal content of serum NAAB of various specificity in young children ranges from -40 to -10 conventional units (c. u.) [3]. At the same time development of pathological processes is accompanied by significant changes of production and serum content of NAAB of corresponding organ specificity. In some cases these changes may be primary (and form the basis of the disorder in question) and in other cases they may be secondary with respect to the pathochemical changes of organs originating from some other (non-immune) etiology [1, 4, 5]. Development of any disease on the molecular level is accompanied with disrupted synthesis and degradation of organ cell components, leading to changes in production of organ-specific NAAB, which may be regarded as marker of the onset (presence) of pathological changes in the organ [6]. Changes of content of these disease-predictors may occur many months or even years prior to clinical manifestation of the disease [3, 5].
منابع مشابه
Interlaboratory testing for the determination of trace amounts of tin and lead in magnesium and magnesium alloys by inductively coupled plasma atomic emission spectrometry.
In order to establish a standard analytical method for the determination of trace amounts of tin and lead in magnesium and its alloys, which could be found in neither JIS nor ISO standards, an interlaboratory testing with inductively coupled plasma atomic emission spectrometry (ICP-AES) has been put into practice. Simple dissolution with nitric and hydrochloric acids and sample nebulization pro...
متن کاملAn analysis of indirect mortality estimation.
Abstract In this paper the robustness of Brass's child-survivorship indirect mortality estimation technique is investigated. An analytical method is developed for studying the error or bias caused in indirect mortality estimates by poor data, badly chosen model functions, and specific demographic assumptions that are often violated in practice. The resulting analytical expressions give insigh...
متن کاملDynamic Assessment in Iranian EFL Classrooms: A Post- method Enquiry
Derived from the emerging paradigm shift in English language teaching and assessment, there has been a renewal of interest in dynamic assessment (DA) to be used as an alternative to the traditional static testing in language classrooms. However, to date, DA practice has been mostly limited to clinical treatments of children with learning disabilities, and it has not been widely incorporated int...
متن کاملAnalytical Method for the Kinetostatic Analysis of the Second-Class RRR Assur Group Allowing for Friction in the Kinematic Pairs
The calculation of forces in the kinematic pairs of mechanisms by inverse dynamics is usually performed without friction considerations. In practice, when examination of articulated mechanisms takes into account friction, the solution of the inverse dynamics results in a complex procedure. If a modular approach for the inverse dynamics is used, then exact solutions are available, but not necess...
متن کاملDeveloping and Using Analytical Methods to Achieve Quality by Design and Efficiency in Drug Development
www.pharmtech.com nalytical method development is a critical part of the drug development process. Analytical methods are used to check the quality of materials that will be used in clinical trials. As drug development progresses toward registration, these and other methods are used to generate information that will enable quality to be designed into the manufacturing processes of drug substanc...
متن کامل